Publications
* Denotes corresponding authorship
2025
Kimball, T.H., Luu, A.N., Gural, B., Lahue, C., Hockett, A., Ravindran, S., Ali, A., Dalal, A., Ardery, S., Sipko, E.S., Kirkland, L.G., Goyal, M., Jensen, B.C., Berlow, R.B., and Rau, C.D. Genetic Determinants of Heart Failure Susceptibility and Response in the Collaborative Cross Mouse Population. 2025. bioRxiv. (Link) Collaboration with Christoph Rau’s lab at UNC.
Sloan, D.E., Matthews, A., Yanagisawa, H., Tedamrongwanish, T., Cannon, K., Simmons, J., Chappell, G., Nicely, N.I., Berlow, R., Kikkawa, M., and Baker, R.W. CCDC32 collaborates with the membrane to assemble the AP-2 clathrin adaptor complex. 2025. bioRxiv. (Link) Collaboration with Rick Baker’s lab at UNC.
2024
Sipko, E.L., Chappell, G.F., and Berlow, R.B*. 2024. Multivalency emerges as a common feature of intrinsically disordered protein interactions. Current Opinion in Structural Biology 84: 102742. (Link)
Day, E.C., Chittari, S.S., Cunha, K.C., Zhao, R.J., Dodds, J.N., Davis, D.C., Baker, E.S., Berlow, R.B., Shea, J-E., Kulkarni, R.U., and Knight, A.S. 2024. A high-throughput workflow to analyze sequence-conformation relationships and explore hydrophobic patterning in disordered peptoids. Chem 10: 3444-3458. (Link) Collaboration with Abigail Knight’s lab at UNC.
Day, E.C., Cunha, K.C., Zhao, J., DeStefano, A.J., Dodds, J.N., Yu, M.A., Han, S., Baker, E.S., Shea, J-E., Berlow, R.B., and Knight, A.S. 2024. Insights into conformational ensembles of compositionally identical disordered peptidomimetics. Polymer Chemistry 15: 2970-2980. (Link) Collaboration with Abigail Knight’s lab at UNC.
2023
Martinez-Yamout, M.A., Nasir, I., Shnitkind, S., Ellis, J.P., Berlow, R.B., Kroon, G., Deniz, A.A., Dyson, H.J., and Wright, P.E. 2023. Glutamine-rich Regions of the Disordered CREB Transactivation Domain Mediate Dynamic Intra- and Intermolecular Interactions. PNAS 120: e2313835120. (Link)
2022
Usui-Ouchi, A., Eade, K., Giles, S., Ideguchi, Y., Ouchi, Y., Aguilar, E., Wei, G., Marra, K.V., Berlow, R.B., and Friedlander, M. 2022. Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis. GLIA 70: 1762-1776. (Link)
Skeens, E., Gadzuk-Shea, M., Shah, D., Bhandari, V., Schweppe, D.K., Berlow, R.B.*, and Lisi, G.P.* 2022. Redox-Dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery. Structure 30: 840-850. (Link)
Berlow, R.B., Dyson, H.J., and Wright, P.E. 2022. Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins. PNAS 119: e2117338119. (Link)
2021
Appling F.D., Berlow, R.B., Stanfield, R.L., Dyson, H.J., and Wright, P.E. 2021. The molecular basis of allostery in a facilitated dissociation process. Structure 29: 1327-1338. (Link)
Eade, K., Gantner, M.L., Hostyk, J.A., Nagasaki, T., Giles, S., Fallon, R., Harkins-Perry, S., Baldini, M., Lim, E.W., Scheppke, L., Dorrell, M.I., Cai, C., Baugh, E.H., Wolock, C.J., Wallace, M., Berlow, R.B., Goldstein, D.B., Metallo, C.M., Friedlander, M., and Allikmets, R. 2021. Serine biosynthesis defect due to haploinsufficiency of phosphoglycerate dehydrogenase (PHGDH) causes retinal disease. Nature Metabolism 3: 366-377. (Link)
2020
Usui-Ouchi, A., Aguilar, E., Murinello, S., Prins, M., Gantner, M.L., Wright, P.E., Berlow, R.B.* and Friedlander, M*. 2020. An allosteric peptide inhibitor of HIF-1a regulates hypoxia-induced retinal neovascularization. PNAS 117: 28297-28306. (Link)
2019
Berlow, R.B., Martinez-Yamout, M.A., Dyson, H.J., and Wright, P.E. 2019. Role of Backbone Dynamics in Modulating the Interactions of Disordered Ligands with the TAZ1 Domain of the CREB-Binding Protein. Biochemistry 58: 1354-1362. (Link)
2018
Berlow, R.B., Dyson, H.J., and Wright, P.E. 2018. Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation. Journal of Molecular Biology 430: 2309-2320. (Link)
Berlow, R.B.* 2018. A dual regulatory role for the disordered C-terminus of protein kinase Ca. Biophysical Journal 114: 1513-1514. (Link)
Berlow, R.B. and Wright, P.E. 2018. Tight complexes from disordered proteins. Nature 555: 37-38. (Link)
2017
Berlow, R.B., Dyson, H.J., and Wright, P.E. 2017. Hypersensitive termination of the hypoxic response by a disordered protein switch. Nature 543: 447-451. (Link)
2015
Berlow, R.B., Dyson, H.J., and Wright, P.E. 2015. Functional advantages of dynamic protein disorder. FEBS Letters 589: 2433-2440. (Link)
2012
Berlow, R.B., Swain, M., Dalal, S., Sweasy, J.B., and Loria, J.P. 2012. Substrate-Dependent Millisecond Domain Motions in DNA Polymerase β. Journal of Molecular Biology 419: 171-182. (Link)
2009
Wang, Y., Berlow, R.B., and Loria, J.P. 2009. Role of Loop-Loop Interactions in Coordinating Motions and Enzymatic Function in Triosephosphate Isomerase. Biochemistry 48: 4548-4556. (Link)
2008
Loria, J.P., Berlow, R.B., and Watt, E.D. 2008. Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion. Accounts of Chemical Research 41: 214-221. (Link)
2007
Berlow, R.B., Igumenova, T.I., and Loria, J.P. 2007. Value of a Hydrogen Bond in Triosephosphate Isomerase Loop Motion. Biochemistry 46: 6001-6010. (Link)
